Thanks for your questions. Answers:
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More -> Config -> Actions -> New will reset you back to a blank layout WITH RANDOM COLORS AND TEXTURES.
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More -> Config -> Actions -> Save will allow you to save your entire layout
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More -> Config -> Actions -> Load will allow you to load layouts
Note that another way to go is to mail layouts to yourself. It's a great way to back stuff up. Let us know if this answer is sufficient or if you need more help, please.
Thanks for using MIDI Designer!